Hello Luc,

I faced this issue a few weeks ago and I was able to fix it. 

Steps: 

- Create the OnReady event in the BinaryPDF block and call OnParametersChanged inside it. 

- Inside OnParametersChanged change the latest Javascript call to this:

// Render big files with blob

const binStr = atob( $parameters.Base64 );

const len = binStr.length;

const arr = new Uint8Array(len);

for (let i = 0; i < len; i++) {

    arr[ i ] = binStr.charCodeAt( i );

}

const blob =  new Blob( [ arr ], { type: 'application/pdf' } );

const url = URL.createObjectURL( blob );

document.getElementById($parameters.iframId).setAttribute("src", URL);

// OLD CODE

//document.getElementById($parameters.iframId).setAttribute("src", "data:application/pdf;base64,"+$parameters.Base64);

With this code the Block can render big PDF files.