Can 2 different application in 2 different zones will be able to access same schema

Is it possible for 2 different application which are hosted in 2 different zones to access the same DB schema.

Are we talking about OutSystems zones as in "selective deployment" or are we talking about different hosting services?

In the second case that implies different infrastructures... is this the case?

If it is, you can expose actions that will write data to the desired schema (via REST or SOAP, for instance).